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| Product Name | Semaphorin 6C, Recombinant, Mouse (Semaphorin Y, Sema Y, SEMA6C, KIAA1869, SEMAY) |
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| Description | Purity ~95% (SDS-PAGE, reducing conditions). Semaphorin 6C (Sema6C; previously Sema Y) is a 120 kD member of the Semaphorin family of axon guidance molecules. The four known Class 6 semaphorins are type I transmembrane glycoproteins that are most like Class 1 invertebrate semaphorins in structure, and exhibit neuropilin- independent binding to specific plexin A receptors.aa identity of Class 6 semaphorins is around 40% overall, but 53-64% within the Sema domain. Sema6C is expressed developmentally in subregions of the central and peripheral nervous systems, heart, and kidney, and primarily in skeletal muscle in adults. Mouse Sema6C cDNA encodes 931 aa, including a 25 aa signal sequence, a 580 aa extracellular domain (ECD) including the Sema domain, a 21 aa transmembrane sequence and a 305 aa cytoplasmic portion. Alternate exon splicing creates a 923 aa short form (Sema6C.3) that is lacking aa 185-224 within the Sema domain, but contains 32 unique aa inserted at aa 586; postnatally, thi |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9WTM3 |
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| Catalog # | S0668-60E |
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| Order / More Info | Semaphorin 6C, Recombinant, Mouse (Semaphorin Y, Sema Y, SEMA6C, KIAA1869, SEMAY) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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