| 产品详情 |
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| Product Name | C-646 |
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| Description | A reversible, cell-permeable pyrazolone p300/CBP HAT inhibitor (Ki = 400 nM), which competes with acetyl-CoA for the p300 Lys-CoA binding pocket. Demonstrates 86% inhibition against p300 at 10 nM. Less than 10% inhibition against serotonin N-acetyltransferase, PCAF, GCN5, Rtt109, Sas, and MOZ HATs in a chemical screening assay. Treatment of C3H 10T1/2 mouse fibroblasts at 25 uM results in an inhibitory effect against basal and TSA-inducible acetylation of histones H3 and H4. Shown to inhibit human cell growth in melanoma and non-small cell-lung cancer cell lines at 10 uM with similar or higher potency than peptide-based bisubstrate p300/CBP HAT inhibitor Lys-CoA-Tat at 25 uM. |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | Activator or Inhibitor |
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| Other Names | p300 HAT inhibitor |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P014-5MG |
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| Price | |
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| Order / More Info | C-646 from ARBOR ASSAYS, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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