| 产品详情 |
| Edit |   |
|---|
| Product Name | Cas9, Nuclear Localization Sequence (NLS), Recombinant, Streptococcus pryrogenes (CRISPR Associated Protein 9) |
|---|
| Description | Purity ~95% (SDS-PAGE). The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 system is the latest RNA-guided, endonuclease tool in genome editing which allows for very specific genomic disruption and replacement. Cas9 Nuclease nuclear localization sequence (NLS), S. pyogenes, is an RNA-guided endonuclease that catalyzes site-specific cleavage of double stranded DNA. Guided by a target specific, single guide RNA (sg RNA), the Cas9 Nuclease NLS Protein serves to cleave both strands of a DNA duplex upon recognition of the target sequence by the sg RNA. The resulting double-stranded break gets repaired by the non-homologous end joining (NHEJ) pathway, leading to a disruption in the open reading frame of the targeted gene. Cas9 Nuclease NLS contains a SV40 T antigen NLS on the C-terminus of the protein. Incorporation of a nuclear localization signal (NLS) aids delivery to the nucleus, thus increasing the rate of genomic DNA cleavage. Source: Recombinant protein corresponding to Streptococcus |
|---|
| Size | 50pmol, 250pmol |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 500562 |
|---|
| Price | |
|---|
| Order / More Info | Cas9, Nuclear Localization Sequence (NLS), Recombinant, Streptococcus pryrogenes (CRISPR Associated Protein 9) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|