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| Product Name | Infliximab ELISA (mAb-based) ELISA Assay Kit |
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| Description | This Eagle Biosciences ELISA Assay Kit is based on Infliximab-specific mouse monoclonal antibody (catcher Ab, ImmunoGuide clone Peri-1). Diluted standards and samples are incubated in the microtiter plate coated with IG-Peri-1 mAb. After incubation, the wells are washed. A horseradish peroxidase (HRP)-conjugated anti-human IgG monoclonal antibody is added and binds to the Fc part of Infliximab. Following incubation, wells are washed and the bound enzymatic activity is detected by addition of chromogen-substrate. The color developed is proportional to the amount of Infliximab in the sample or standard. Results of samples can be determined by using the standard curve. Binding of Infliximab to the solid phase, pre-coated with Peri-1, is inhibited by recombinant human TNF-α or Antibody to Infliximab (ATI) in a concentration dependent manner. Therefore, the ImmunoGuide Infliximab ELISA (mAb-based) measures the free form of Infliximab. Sample Types: serum, plasma. Range: 6 - 200 ng/mL. Sensitivity: 2 ng/mL. Time: 2 hours • The drug Infliximab (trade names Remicade®, Remsima®, and Inflectra®) is a chimeric monoclonal antibody and used to treat auto-immune disorders. Infliximab reduces the amount of active human tumor necrosis factor alpha (hTNF-α) in the patient by binding to it and preventing it from signaling the receptors for TNF-α on the surface of various cell types. TNF-α is one of the key cytokines that triggers and sustains the inflammatory reactions. Infliximab is used for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, ulcerative colitis. The specificity of this testsystem is achieved by using a monoclonal antibody named Peri-1 mAb for the coating of the microtiter plate. This antibody is specific for Infliximab only (regardless whether Remicade®, Remsima®, or Inflectra®) and does not cross react with other TNF-α catchers. In this context, identification of biomarkers for (non-)response and risk factors for adverse drug reactions relating to serum concentrations and therapeutic drug monitoring of Infliximab would be very helpful. |
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| Size | 1 x 96 well |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Infliximab, Remicade, Remsima |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | IG-AB101 |
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| Order / More Info | Infliximab ELISA (mAb-based) ELISA Assay Kit from EAGLE BIOSCIENCES INC. |
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| Product Specific References | n/a |
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