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| Product Name | Dkk-2, aa1-259, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Dickkopf related protein 2 (Dkk-2) is a member of the Dickkopf family of secreted Wnt modulators (1-3). Dkk proteins contain a signal peptide and two conserved cysteine-rich domains that are separated by a linker region. The second cysteine-rich domain mediates Dkk-2 binding activities, and its interaction with B-propeller domains of LRP-5/6 has been mapped (2-4, 7). The 226aa, 35kD mature human Dkk-2 shares 96%, 97%, 97%, 97%, 97% and 98% aa identity with mouse, rat, canine, equine, bovine and porcine Dkk-2, respectively. Mouse Dkk-2 can activate the canonical Wnt signaling pathway in Xenopus embryos, showing evolutionary conservation of function (5). Dkk proteins modify Wnt engagement of a receptor complex composed of a Frizzled protein and a low-density lipoprotein receptor-related protein, either LRP-5 or LRP-6 (3). Also, Kremen-1 and Kremen-2 are high affinity receptors for Dkk-1 and Dkk-2 (9). When LRP-6 is overexpressed, direct high-affinity binding of Dk |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Dkk-2, aa1-259, Recombinant, Human (Dickkopf-2, Dickkopf-related Protein 2 Precursor, Dkk-2, hDkk-2, UNQ682/PRO1316) |
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| Gene, Accession, CAS # | Accession: NP_055236 |
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| Catalog # | D3795-01C |
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| Order / More Info | Dkk-2, aa1-259, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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