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| Product Name | Proguanylin, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Three-step procedure using IMAC and size exclusion chromatography before and after refolding. Heat-stable enterotoxins (STa) are small, cysteine-rich peptides secreted by Escherichia coli that are able to induce diarrhea through the stimulation of an intestine- specific receptor-guanylyl cyclase known as STaR. Binding of STa to STaR induces a dramatic increase in the cGMP content of the cell; the increase, in turn, inhibits salt absorption and stimulates chloride secretion. This imbalance of ions is accompanied by a massive accumulation of water in the gut that gives rise to the diarrhea and dehydration characteristic of enterotoxin activity. The identification of a receptor for STa on intestinal brush border membranes suggested the existence of an endogenous activator, described guanylin, a 15aa peptide purified from rat small intestine, as a potential ligand for the STaR. This peptide shares sequence similarity with STa; see also uroguanylin. The molecular clo |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | Proguanylin, Recombinant, Human (Guanylin Precursor, Guanylate Cyclase Activator 2A, Guanylate Cyclase-activating Protein 1, Gap-Iguca2, Stara, Guanylin) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209153 |
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| Order / More Info | Proguanylin, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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