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| Product Name | Proheparin-binding EGF-like Growth Factor [Cleaved into: Heparin-binding EGF-like Growth Factor, active |
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| Description | Purity ≥97% as determined by SDS-PAGE and HPLC. Proheparin-binding EGF-like Growth Factor [Cleaved into: Heparin-binding EGF-like Growth Factor, active (HBEGF), Recombinant, Human. Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 1ng/ml, corresponding to a specific activity of 1.0x10e6 IU/mg. |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HB-EGF, Diphtheria toxin receptor, DT-R |
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| Gene, Accession, CAS # | HBEGF_HUMAN, SwissProt: Q99075 |
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| Catalog # | 348212 |
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| Order / More Info | Proheparin-binding EGF-like Growth Factor [Cleaved into: Heparin-binding EGF-like Growth Factor, active from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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