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| Product Name | PAI2, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE and HPLC). PAI-2 is an inhibitory serpin expressed mainly in keratinocytes, activated monocytes, and placental trophoblasts. It exists predominantly as a 47kD nonglycosylated intracellular protein which can be induced to be secreted as 60kD glycoprotein. The physiological relevance of this property, which is neither a consequence of any mutation in the PAI-2 gene nor associated with any known disorder, is still unclear. However, it appears that the formation of intracellular dormant polymers may be important for the controlled release of the inhibitor from PAI-2 producing cells. Plasma levels of PAI-2 are usually low or undetectable, except during pregnancy and in some forms of monocytic leukemia. Secretion of PAI-2 from the placenta normally occurs during the third trimester of pregnancy and accounts for the dramatic increase in PAI-2 levels (up to 250ng/ml), which are maintained at these levels until postpartum, and then rapidly decline. In addition to its vital |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PAI2, Recombinant, Human (Plasminogen Activator Inhibitor 2, PAI-2, Placental Plasminogen Activator Inhibitor, Monocyte Arg-serpin, Urokinase Inhibitor, Serpin B2, PLANH2, SERPINB2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149560 |
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| Price | |
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| Order / More Info | PAI2, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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