| 产品详情 |
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| Product Name | AC 710 |
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| Description | Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active. Purity 99%. MW (observed): 562.7 |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide |
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| Gene, Accession, CAS # | CAS: 1351522-04-7 |
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| Catalog # | 5013/50 |
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| Price | |
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| Order / More Info | AC 710 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 29571051 |
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| 产品资料 |
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