| 产品详情 |
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| Product Name | KC7F2 |
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| Description | Purity >98%. Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor composed of a HIF-1Alpha subunit and HIF-1Beta subunit. The HIF-1Alpha subunit is regulated by cellular oxygen levels and therefore plays an important role in maintaining cellular oxygen homeostasis. KC7F2 is an inhibitor of HIF-1Alpha protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K). It inhibits hypoxia-induced expression of several HIF target genes, such as carbonic anhydrase IX, matrix metalloproteinase 2, enolase 1, and endothelin 1. KC7F2 is cytotoxic to a variety of cancer cell lines with an IC50 value of 15-25 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N,N'-(dithiodi-2,1-ethanediyl)bis [2,5-dichloro-benzenesulfonamide |
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| Gene, Accession, CAS # | CAS: 927822-86-4 |
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| Catalog # | LS-H8332 |
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| Price | |
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| Order / More Info | KC7F2 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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