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| Product Name | JNJ-10397049 |
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| Description | Purity >98%. JNJ-10397049 is a potent, selective, and bioavailable antagonist of the orexin-2 receptor (OX2R) (KB = 4.5 nM for OX2R versus 1.1 µM for OX1R). It has no significant affinity for over 50 other neurotransmitters or neuropeptide receptors. Applied subcutaneously to rats, JNJ-10397049 decreases the latency to persistent sleep and increases persistent sleep time. This compound produces a widespread attenuation of D-amphetamine-induced relative cerebrovascular signal, with prominent cortical involvement, in rat brains assessed by functional magnetic resonance imaging. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(2,4-dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea |
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| Gene, Accession, CAS # | CAS: 708275-58-5 |
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| Catalog # | LS-H8292 |
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| Order / More Info | JNJ-10397049 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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