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| Product Name | JNJ-26854165 |
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| Description | Purity >98%. The E3 ubiquitin ligase known as murine double minute 2 (MDM2; HDM2 in humans) binds to and then ubiquitinates several proteins, most notably the tumor suppressor p53. JNJ-26854165 is an antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM). It induces p53-mediated transcription culminating in apoptotic death of acute leukemia cells. JNJ-26854165 is orally bioavailable and has anti-proliferative as well as apoptotic actions in various tumor models. As MDM2 interacts with and modulates several targets in addition to p53, JNJ-26854165 affects multiple signaling pathways. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N1 -[2-(1H-indol-3-yl)ethyl]-N4 -4-pyridinyl-1,4-benzenediamine, Serdemetan |
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| Gene, Accession, CAS # | CAS: 881202-45-5 |
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| Catalog # | LS-H8295 |
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| Order / More Info | JNJ-26854165 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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