| 产品详情 |
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| Product Name | Platensimycin |
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| Description | Purity >95%. Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 µM). It targets the Beta-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50 s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance. PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[[3-[(1S,3S,4S,9S)-1,4,5,8,9,9aR-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5aS-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-benzoic acid, PTM |
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| Gene, Accession, CAS # | CAS: 835876-32-9 |
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| Catalog # | LS-H9449 |
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| Order / More Info | Platensimycin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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