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| Product Name | Hepcidin, 25aa, Human, Control Peptide |
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| Description | Highly purified. Control peptide for H2008-50 (antiserum) and H2008-51 (affinity purified antibody). Hepcidin (Hepc, hepatic bactericidal protein) or LEAP (liver expressed antimicrobial peptide) is small, cysteine-rich peptide, antimicrobial peptide similar to defensins and thionins. Hepcidin (unprocessed, proprotein in mouse 83aa, rat/human 84aa) are almost exclusively produced in liver. Human hepcidin is produced from 84aa precursor, including a putative 24aa signal peptide. The secreted form of hepcidin in blood and urine consists of C-terminal 20, 22 or 25aa residues. The link between hepcidins and iron metabolism is that hepcidin expression is abolished in mice exhibiting iron-overload due to the targeted disruption of USF2 (upstream stimulatory factor 2) gene resembling the situation in hfe-/- mice. The human gene is located at chromosome 19, in close proximity with Usf2 gene. Hepcidin levels are increased in iron loading and in beta-2 microglobulin knockout mice. Hepcidins are d |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | Hepcidin, 25aa, Human, Control Peptide (Hepc, LEAP, Hepatic Bactericidal Protein, Liver Expressed Antimicrobial Peptide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H2008-52 |
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| Order / More Info | Hepcidin, 25aa, Human, Control Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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