| 产品详情 |
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| Product Name | ETP-46464 |
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| Description | Purity >98%. ETP-46464 is an inhibitor of the DNA damage response kinase Ataxia-telangiectasia mutated (ATM)- and Rad3-related (ATR) with an IC50 value of 25 nM. It also inhibits mTOR and DNA-dependent protein kinase (IC50 s = 0.6 and 36 nM, respectively), and is moderately active against PI3KAlpha and ATM (IC50 s = 170 and 545 nM, respectively). Pharmacological inhibition of ATR is reported to generate replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks. ETP-46464 has been shown to be toxic to p53-deficient cells, which is exacerbated by replicative stress-generating conditions such as the overexpression of cyclin E. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | a,a-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile, ATM Inhibitor III, ATR Inhibitor III |
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| Gene, Accession, CAS # | CAS: 1345675-02-6 |
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| Catalog # | LS-H7735 |
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| Order / More Info | ETP-46464 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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