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| Product Name | EW-7197 |
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| Description | Purity >98%. EW-7197 is a potent inhibitor of activin receptor-like kinase 5 (ALK5, also known as TGF-Beta receptor type 1; IC50 = 12.9 nM). It also inhibits ALK2 and ALK4 at nanomolar concentrations. EW-7197 blocks TGF-Beta/Smad signaling, cell migration, invasion, and lung metastasis in mouse mammary tumor virus/c-Neu mice and 4TI orthotopic-grafted mice. It also inhibits epithelial-to-mesenchymal transition (EMT) in TGF-Beta-treated breast cancer cells. EW-7197 is used to block TGF-Beta signaling and EMT in animal models of cancer and fibrosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine |
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| Gene, Accession, CAS # | CAS: 1352608-82-2 |
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| Catalog # | LS-H7742 |
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| Order / More Info | EW-7197 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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