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| Product Name | NCAM-L1, Recombinant, Mouse |
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| Description | Purity ~95% (SDS-PAGE, reducing conditions). Neural cell adhesion molecule L1 (NCAM-L1; also L1-CAM, L1, and CD171) is a 200-220kD type I transmembrane glycoprotein of the immunoglobulin superfamily and L1/neurofascin/NgCAM family. NCAM-L1 is expressed by neurons, especially by growing axons on their growth cones. Non-neuronal cells such as Schwann cells, astrocytes, epithelial cells, and cells of myelomonocytic and lymphoid origin also express NCAM-L1. Full length mouse NCAM-L1 is synthesized as a 1260aa precursor that contains a 19aa signal sequence, a 1104aa extracellular domain (ECD), a 23aa transmembrane region, and a 114aa cytoplasmic tail that is highly conserved. The ECD contains six Ig-like C2-type domains, five fibronectin type III domains, and 21 potential sites for N-linked glycosylation. Mouse NCAM-L1 shares 88% aa sequence identity with human NCAM-L1. NCAM-L1 is critical for neural development. Specifically, NCAM-L1 plays a key role in neuronal cell migration, axon outgro |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NCAM-L1, Recombinant, Mouse (Neural Cell Adhesion Molecule L1, N-CAM-L1, NCAM-L1, CD171, L1cam, Caml1) |
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| Gene, Accession, CAS # | SwissProt: P11627 |
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| Catalog # | N0547-01 |
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| Order / More Info | NCAM-L1, Recombinant, Mouse from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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