产品名称 c-FOS (Human) Transcription Factor Activity Assay Kit from CREATIVE BIOMART
产品货号 Kit-2230
产品价格 现货询价,电话:010-67529703
产品规格 100 assays
产品品牌 CREATIVE BIOMART
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Product Namec-FOS (Human) Transcription Factor Activity Assay Kit
DescriptionActivator protein-1 (AP-1) is a sequence-specific transcriptional activator composed of members of the Jun (c-Jun, JunB, and JunD) and Fos (c-FOS, FosB, Fra1, and Fra2) families in formats of homo- and heterodimers. These proteins belong to the bZIP group of DNA binding proteins with the ability to a common consensus sequence-defined AP-1-binding site. Inside cells, AP-1 activity is induced by an incredible diversity of signals, including growth factors, cellular stress, ionizing and ultraviolet irradiation, DNA damage, oxidative stress, neuronal depolarization antigen binding by T or B lymphocytes, and cytokines. The mechanisms involved in the induction of AP-1 activity are either through changing the expression of AP-1 components or post-translation modification or both to regulate their trans-activity positively or negatively. For example, stimulation by growth factors or by activating mutations in cytoplasmic effectors such as ras and raf, results in AP-1 activation by triggering the ERK signaling pathway. On the other hand, AP-1 responses to proinflammatory cytokines and UV radiation are mostly dependent on two other MAPK cascades, JNK and p38 of MAP kinases. As a result, the AP-1 regulates different target genes executing different biological functions such as cell proliferation, differentiation, apoptosis, or cell death. The c-FOS Transcription Factor-Activity Assay kit is a non-radioactive transcription factor assay with an ELISA format. It offers an easy, speedy, sensitive and high-throughput method to detect the activation of transcription factors.
Size100 assays
Concentrationn/a
ApplicationsDetecting the c-FOS in human nuclear extraction and whole lysates.
Other Namesn/a
Gene, Accession, CAS #n/a
Catalog #Kit-2230
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Order / More Infoc-FOS (Human) Transcription Factor Activity Assay Kit from CREATIVE BIOMART
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