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| Product Name | Centrin-2, Recombinant, Human, aa1-172, His-SUMO-Tag (CETN2) |
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| Description | Purity ~90% (SDS-PAGE). Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to re |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Caltractin isoform 1 |
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| Gene, Accession, CAS # | SwissProt: P41208 |
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| Catalog # | 372724 |
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| Order / More Info | Centrin-2, Recombinant, Human, aa1-172, His-SUMO-Tag (CETN2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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