| 产品详情 |
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| Product Name | JQ1 Enantiomers Set |
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| Description | Purity ~99% (HPLC). A cell-permeable I-BET class of thienodiazepine derivative whose (S)-(+), but not (R)-(-), enantiomer is shown to target both bromodomains (BD1 & BD2) of BET family members BRD2, BRD3, BRD4, and BRD6/BRDT in a Kac- (epsilon-N-acetylated lysine) competitive manner, exhibiting little affinity toward 23 other BD-containing proteins, BRD1 and BRD9, and little or no activity against a panel of more than 50 receptors, ion channels, and transporters. Effectively inhibits the oncogenic BRD4-NUT fusion-dependent NUT midline carcinoma and c-Myc oncoprotein-dependent multiple myeloma proliferation both in cultures (IC50 <1uM) in vitro and in mice (50mg/kg/day i.p.) in vivo. Also reported to cross the blood-testis boundary in male mice and effectively block BRDT-mediated spermatogenesis without affecting hormone levels. The set contains 5 mg of the active (S)-(+)-JQ1 (540696) and 5mg of the inactive (R)-(-) enantiomer. Set Contents: (S)-(+)-JQ1 Enantiomer: 5mg (R)-(-) JQ1 Enant |
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| Size | 1 set |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JQ1 Enantiomers Set ((S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, SGCBD01, BRD2 Inhibitor III, BRD3 Inhibitor II, BRD4 Inhibitor III, BRD6 Inhibitor I, BRDT Inhibitor I) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217487 |
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| Order / More Info | JQ1 Enantiomers Set from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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