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| Product Name | MutaGEL® OxStress I (eNOS/ NAD(P)H Oxidase) (24) |
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| Description | With the Eagle Biosciences MutaGEL® Oxstress I two DNA regions specific for the critical gene parts of eNOS and NAD(P)H Oxidase are amplified in parallel reactions. The amplification products are then treated with a mix of restriction enzymes, which are sensitive for the negative sequence variant of each gene - in parallel as well - such that in the following gel the genotype of the probe can be recognised for both polymorphisms from the length of the resulting restriction fragments (RFLP method). Sample Types: DNA. • Within the metabolic status named oxidative stress the production of molecules with free reactive electrones from e.g. glycolysis is not equalled by its normal potent lipidic or enzymatic electron acceptors. This causes diabetes, cancer and aging. The levels of several indicative molecules vary under the influence of some common DNA polymorphisms of enzymes, which metabolize the agonists of the radicalic or nonradicalic oxidants - mainly superoxide and hydroxide anion - such as T-786C of the NOSynthase promotor, C242T (His72Tyr) in a subunit of the NAD(P)H oxidase macromolecule. Additionally, the common complete deletion of glutathion-S-transferase genes M1 and T1 (see ``MutaGEL® GST-M1/T1'') as well as sequence variation of superoxide-dismutase SOD2 and catalase (see ``MutaGEL® Oxstress II'') influence the radicalic situation in the body. |
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| Size | 24 samples |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | genotypes T-786C (promotor region) of the endothelial NO Synthase gene (NOS3) and C242T (His72Tyr) of the NAD(P)H Oxidase subunit CYBA |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | KE09008 |
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| Order / More Info | MutaGEL® OxStress I (eNOS/ NAD(P)H Oxidase) (24) from EAGLE BIOSCIENCES INC. |
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| Product Specific References | n/a |
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