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| Product Name | SR 1824 |
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| Description | Purity >98%. Peroxisome proliferator-activated receptor Gamma (PPARGamma) is activated by the anti-diabetes drugs known as thiazolidinediones, including rosiglitazone and pioglitazone . Phosphorylation of PPARGamma by cyclin-dependent kinase 5 (Cdk5) causes dysregulation of genes whose expression is altered in obesity, including adiponectin. SR 1824 is a non-agonist PPARGamma ligand (Ki = 10 nM) which blocks Cdk5-mediated phosphorylation. It does not inhibit activation of PPARGamma by rosiglitazone . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (S)-4'-((5-((1-(4-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid |
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| Gene, Accession, CAS # | CAS: 1338259-06-5 |
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| Catalog # | LS-H10012 |
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| Order / More Info | SR 1824 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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