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| Product Name | SR 3335 |
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| Description | Purity >94%. The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of ROR alpha, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It is without effect on ROR beta, ROR gamma, farnesoid X receptor, or liver X receptor alpha . SR 3335 evokes ROR alpha -dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-2-thiophenesulfonamide, ML176 |
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| Gene, Accession, CAS # | CAS: 293753-05-6 |
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| Catalog # | LS-H85 |
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| Order / More Info | SR 3335 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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