| 产品详情 |
| Edit |   |
|---|
| Product Name | SR 2211 |
|---|
| Description | Purity >98%. Retinoic acid receptor-related nuclear receptor Gamma (RORGamma) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH 17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 2211 selectively binds RORGamma (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORGamma activity (IC50 = 320 nM). It has minimal effects on RORAlpha, LXRAlpha, and FXR activities. SR 2211 significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 µM. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2-fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis (trifluoromethyl)-[1,1'-biphenyl]-4-methanol |
|---|
| Gene, Accession, CAS # | CAS: 1359164-11-6 |
|---|
| Catalog # | LS-H10010 |
|---|
| Price | |
|---|
| Order / More Info | SR 2211 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|