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| Product Name | Anti-Myelin Auto-Antibodies ELISA |
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| Description | Myelin-specific proteins have been purified from bovine brain and used for coating of microtiterplates: Myelin-oligodendrocyticglycoprotein (MOG); Myelin Basic Protein (MBP); Myelin-associated Glycoprotein (MAG); Proteolipoprotein (PLP); Alpha-B-Crystallin (CRY). The antibodies in the samples bind specifically to the immobilized Antigenss. IgG- or IgM specific biotinylated antibodies together with a streptavidin peroxidase conjugate are employed for the detection of the bound antibodies of the sample. A chemical reaction catalyzed by the peroxidase results in a colour change of the substrate, which is stopped after defined period of time. The colour intensity correlates positive with the amount of specific antibodies bound. To assess the quantity in each run a ready-to-use diluted human serum is used for calibration. The amount of specific antibody in the standard has been determined by titration. Thus, this assay quantifies the specific antibodies in the sample in arbitrary Mediagnost Units. Sample Types: serum, csf. Sensitivity: 0.014 ng/ml. Time: 4.75 hours • Several neurodegenerative diseases are at least partially caused by auto immunreactions. Inflammatory processes result in neuronal loss. Mostly, T-cell dependent immunity is in the central part of the pathological concept. But it is known that in some neurological diseases like multiple sclerosis B-cell dependent immunity is also of relevance in disease progress. Thus, antibodies are a well established means in differential diagnostics of neuronal diseases e.g. by the detection of oligoclonal bands or measurement of specific antibodies against neuronal Proteins like aquaporin IV. This assay allows the quantitative detection of Antigens specific IgG and IgM antibodies in serum samples and cerebrospinal fluid. |
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| Size | 2 x 96well |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Anti-Myelin Auto-Antibodies ELISA |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E100 |
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| Order / More Info | Anti-Myelin Auto-Antibodies ELISA from EAGLE BIOSCIENCES INC. |
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| Product Specific References | n/a |
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