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| Product Name | TSG / TWSG1 Protein (Recombinant) (Cys26-Phe223) |
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| Description | Purity >95% by SDS-PAGE and HPLC, MW: 30-33 kDa (SDS-PAGE). Twisted gastrulation (TWSG1 or TSG) is a cysteine-rich 24 kDa glycoprotein. It is a secreted BMP binding protein that modulates BMP ligand availability in extracellular space. Human TSG shares 98% aa identity with mouse and rat TSG, and 99.5% aa identity with canine, equine, bovine and porcine TSG. Glycosylation and bioactivity of TWSG1 recombinant proteins vary markedly by cellular source. Non-glycosylated hTWSG1 made in E. coli has both reduced affinity for BMPs, as shown by surface plasmon resonance analysis, and reduced BMP inhibitory activity in a mandibular explant culture system compared to glycosylated proteins made in insect cells or mouse myeloma cells. Recombinant human Twisted Gastrulation (TSG), produced in HEK 293 cells is a polypeptide chain containing 211 amino acids. A fully biologically active molecule, rhTSG has a molecular mass of 30~33 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TWSG1, TSG |
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| Gene, Accession, CAS # | TWSG1, Gene ID: 57045 |
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| Catalog # | LS-G27013 |
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| Order / More Info | TSG / TWSG1 Protein (Recombinant) (Cys26-Phe223) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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