| 产品详情 |
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| Product Name | Akt, Substrate Peptide (Rac PKa, PKBa) |
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| Description | Purity ≥ 80%. AKT is a serine/threonine kinase that enhances cell proliferation and inhibits apoptosis when activated. Akt associates with PI(3,4,5)P3 at the cell membrane through its pleckstrin homology domain and is activated through phosphorylation. 3-Phosphoinositide-dependent kinase-1 (PDK1) has been shown to first phosphorylate Akt at Thr308, then a second kinase phosphorylates Akt at position Ser473. In turn, Akt phosphorylates a host of proteins including the proapoptotic proteins BAD and pro-caspase-9, GSK3, p21WAF1, MDM2, and the forkhead (FKHR) family of transcription factors. Peptide Sequence (linear): R-P-R-A-A-T-F (Arg-Pro-Arg-Ala-Ala-Thr-Phe) MW: 817 Applications: Suitable for use as a substrate for Protein Kinase B alpha (PKB/AKT; Km = 5uM). |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A1124-07D |
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| Order / More Info | Akt, Substrate Peptide (Rac PKa, PKBa) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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