| 产品详情 |
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| Antigenic Specificity | ABCB11 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ABCB11 Polyclonal Antibody. ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | Entrez: 27413, 8647; Uniprot: O95342, Q9QY30 |
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| Catalog # | PA5-13105 |
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| Price | |
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| Order / More Info | ABCB11 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 25771127 |
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