| 产品详情 |
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| Product Name | DRB |
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| Description | Purity >98%. DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 µM)1, Cdk7 (IC50 = ~20 µM)2, Cdk8 (IC50 = ~20 µM)3, and Cdk9 (IC50 = 3 µM). Through inhibition of certain CTD kinases, DRB inhibits an elongation step during RNA polymerase II transcription5, which can trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells. DRB can also inhibit HIV transcription (IC50 = ~4 µM) by targeting elongation enhanced by the HIV-encoded transactivator Tat. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5,6-dichloro-1-Beta-D-ribofuranosyl-1H-benzimidazole, Benzimidazole, NSC 401575 |
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| Gene, Accession, CAS # | CAS: 53-85-0 |
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| Catalog # | LS-H7591 |
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| Price | |
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| Order / More Info | DRB from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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