| 产品详情 |
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| Product Name | 6-OAU |
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| Description | Purity >97%. GPR84 is a G alpha i protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is expressed in leukocytes and its expression is further induced by LPS. 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM). It has insignificant actions at a panel of 69 other receptors, channels, or transporters. 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF- alpha production by LPS-treated U937 macrophages. In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated alpha protein) when delivered intravenously. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-(octylamino)-2,4(1H,3H)-pyrimidinedione |
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| Gene, Accession, CAS # | CAS: 83797-69-7 |
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| Catalog # | LS-H145 |
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| Order / More Info | 6-OAU from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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