| 产品详情 |
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| Product Name | Mitochondrial Pyruvate Carrier Inhibitor, UK5099 |
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| Description | Purity ~99% (HPLC). A cell-permeable alpha-cyanocinnamate compound that acts as a rapid, active site thiol modifying, time-dependent and non-competitive inhibitor of bi-directional pyruvate transport across plasma membranes in yeast, bacteria, Drosophila, and humans (IC50 = 50nM in rat heart mitochondria; Ki ≤ 1uM) with excellent selectivity over monocarboxylates and anions. Shown to significantly decrease pyruvate-driven respiration, enhance glucose uptake and activate AMPK (2uM in human myocytes and skeletal muscle myotubes). Solubility: DMSO Primary Target: mitochondria |
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| Size | 5mg, 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mitochondrial Pyruvate Carrier Inhibitor, UK5099 ((E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid, (E)-2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, MPC Inhibitor, PF-1005023) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217555 |
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| Order / More Info | Mitochondrial Pyruvate Carrier Inhibitor, UK5099 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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