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| Product Name | PI 3-K Inhibitor XVIII |
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| Description | Purity ~95% (HPLC). An N-myristoylated cell-permeable PI 3-K p110 beta-derived G beta-gamma-binding peptide (aa514-537 in p110 beta C2-helical linker region) that prevents G beta-gamma-, but not RTK-, mediated p100 beta activation both in cell-free assays (1uM) and in cultures (30uM in p110 beta/p85/Akt/G beta-gamma-transfected HEK 293E cells) without affecting basal p100 beta activity, p110 beta-Rab5 interaction, nor G beta-gamma-dependent activation of adenylyl cyclase or p101-p110-gamma dimer. The ATP-competitive p110 beta inhibitior TGX-221 can be used in conjunction for studying G beta-gamma dependency of p110 beta-mediated cellular functions. Sequence: N-Myr-Lys-Ala-Ala-Glu-Ile-Ala-Ser-Ser-Asp-Ser-Ala-Asn-Val-Ser-Ser-Arg-Gly-Gly-Lys-Lys-Phe-Leu-Pro-Val-NH2 Solubility: H2O Primary Target: Gbeta-gamma subunit of G-proteins Molar Mass: 2629.1 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PI 3-K Inhibitor XVIII (p110 beta-G beta gamma Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFLPV-NH2) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217655 |
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| Order / More Info | PI 3-K Inhibitor XVIII from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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