| 产品详情 |
| Edit |   |
|---|
| Product Name | PI 3-K/mTOR Inhibitor III, PKI-179 |
|---|
| Description | Purity ~98% (HPLC). A cell-permeable triazinyl-phenyl-pyridinylurea compound that acts as a potent inhibitor against mTOR (IC50=0.42nM) and PI 3-K (IC50=8, 24, 74, 77, 14, and 11nM against isoform a, b, g,d, a E545K mutant, and a H1047R mutant, respectively) activities, exhibiting much reduced or little activity against a panel of 361 other kinases (IC50 >50uM), Cytochrome CYP isoforms, or hERG. It is reported to be orally available in mouse, rat, monkey, and dog species, and effectively suppress cancer growth both in cultures in vitro (IC50=22 and 29nM, respectively, against MDA361 and PC3mm2) and in mice in vivo (by 30% of control MDA361 tumor size on day 42; 50mg/kg/day p.o.) via apoptosis induction as a result of Akt/mTOR pathway inhibition. Formula: C25H28N8O3•H2O Solubility: DMSO Molecular Weight: 506.6 |
|---|
| Size | 5mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | PI 3-K/mTOR Inhibitor III, PKI-179 (1-(4-(4-(3-Oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)-phenyl)-3-(pyridin-4-yl)urea, hydrate, N-(4-(4-(4-Morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl)phenyl)-N'-4-pyridinylurea, hydrate, PI 3-K Inhibitor XVII, mTOR Inhibitor X) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217656 |
|---|
| Price | |
|---|
| Order / More Info | PI 3-K/mTOR Inhibitor III, PKI-179 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|