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| Product Name | PI3K, p110 alpha, p85 alpha, Recombinant, Human, His-Tag (Phosphoinositide 3 Kinase) |
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| Description | Purified (~70-90%). The PI3K comprises of a 110kD catalytic subunit and a 85kD regulatory subunit. A number of isoforms of the 110kD catalytic subunit and the 85kD regulatory subunit exist in cells. The p110a catalytic subunit (PIK3CA) is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants. PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of p110a is essential for vascular development and inactivation of p110a leads to severe defects in angiogenic sprouting and vascular remodeling. Source: Recombinant protein corresponding to human PI3K, fused to His-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~86kD, 111kD Specific Activity: 52nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_006218 |
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| Catalog # | 500362 |
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| Order / More Info | PI3K, p110 alpha, p85 alpha, Recombinant, Human, His-Tag (Phosphoinositide 3 Kinase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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