| 产品详情 |
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| Product Name | Riociguat |
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| Description | Purity >98%. Riociguat is a stimulator of soluble guanylate cyclase (sGC). It increases the activity of sGC in vitro by up to 73-fold and acts in synergy with nitric oxide to increase sGC activity up to 122-fold. At concentrations up to 10 µM, riociguat does not inhibit cGMP-specific nor cGMP-metabolizing phosphodiesterases, such as PDE1, PDE2, PDE5, or PDE9. Riociguat has been shown to promote vasodilation in several pre-clinical animal models of hypertension and has been evaluated in phase II and III clinical studies of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbamic acid, methyl ester, BAY 63-2521 |
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| Gene, Accession, CAS # | CAS: 625115-55-1 |
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| Catalog # | LS-H9727 |
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| Order / More Info | Riociguat from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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