| 产品详情 |
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| Product Name | BRD73954 |
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| Description | Purity >95%. HDACs are a family of proteins with diverse roles. HDAC6 is a class IIb histone that deacetylates cytoplasmic proteins, including tubulin, heat shock protein 90, and cortactin, and has roles in cell adhesion and motility. HDAC8, on the other hand, is a class I histone that primarily targets nuclear proteins, including histones and cohesins, and regulates gene expression. BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50 s = 36 and 120 nM, respectively). It is at least 75-fold less effective against other HDAC isoforms. At 10 µM, BRD73954 treatment results in a robust increase in acetylation of Alpha-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N1 -hydroxy-N3 -(2-phenylethyl)-1,3-benzenedicarboxamide |
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| Gene, Accession, CAS # | CAS: 1440209-96-0 |
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| Catalog # | LS-H6893 |
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| Price | |
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| Order / More Info | BRD73954 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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