| 产品详情 |
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| Product Name | 5-Aminosalicylic Acid |
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| Description | Purity >99%. 5-Aminosalicylic acid (5-ASA) is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn's disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 µM, respectively. In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2 (PGE2 ) production, but does reduce leukotriene B4 (LTB4 ) synthesis approx. 50%. In ionophore-stimulated human leukocytes, 400 µM 5-ASA reduces LTB4 production approximately 20%. 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-amino-2-hydroxy-benzoic acid, 5-ASA, Mesalazine |
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| Gene, Accession, CAS # | CAS: 89-57-6 |
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| Catalog # | LS-H6194 |
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| Price | |
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| Order / More Info | 5-Aminosalicylic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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