| 产品详情 |
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| Product Name | Naphthofluorescein |
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| Description | Purity >98%. Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 µM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1 -MMP), resulting in decreased levels of active MT1 -MMP. This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1- MMP. Napthofluorescein significantly inhibits the invasion by the human fibrosarcoma cell line, HT1080. The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3,11-dihydroxy-spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one, CCG 8295 |
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| Gene, Accession, CAS # | CAS: 61419-02-1 |
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| Catalog # | LS-H8910 |
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| Order / More Info | Naphthofluorescein from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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