| 产品详情 |
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| Product Name | N-Arachidonyl Maleimide |
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| Description | Purity >98%. 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB1 ) and peripheral cannabinoid (CB2 ) receptors. 2-AG is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain. Monoacylglycerol lipase (MGL) hydrolyzes 2-AG to arachidonic acid and glycerol, thereby terminating its biological actions. N-Arachidonyl maleimide (NAM) is a potent, irreversible inhibitor of monoacylglycerol lipase (MGL) or MGL-like activity in rat cerebellar membranes, exhibiting an IC50 value of 140 nM. Inhibition of MGL by the sulfhydryl-reactive maleimide group of NAM suggests a critical cysteine residue is present in the substrate-binding site of the enzyme. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | eicosa-5Z,8Z,11Z,14Z-tetraenyl-1-pyrrole-2,5-dione, NAM |
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| Gene, Accession, CAS # | CAS: 876305-42-9 |
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| Catalog # | LS-H8915 |
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| Order / More Info | N-Arachidonyl Maleimide from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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