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| Product Name | Necrostatin-1 |
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| Description | Purity >98%. Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-Alpha (TNF-Alpha) induced necrosis. Necrostatin-1 is an inhibitor of RIP1 kinase that prevents the death of TNF-Alpha-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM. It has been used to investigate the pathological importance of necroptosis in ischemic brain injury and myocardial infarction. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Nec-1 |
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| Gene, Accession, CAS # | CAS: 4311-88-0 |
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| Catalog # | LS-H8957 |
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| Order / More Info | Necrostatin-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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