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| Product Name | Cariporide |
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| Description | Purity >95%. The sodium-hydrogen exchanger isoform-1 (NHE-1) is the predominant isoform of the Na+ /H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis. It plays an important role in the myocardial response to ischemia-reperfusion. Cariporide is a benzoylguanidine compound that inhibits NHE-1 with IC50 values ranging from 0.03-3.4 µM. It displays selectivity for NHE-1 over NHE-2, NHE-3, and NHE-5 (IC50 s = 4.3-62, 1->100, and >30 µM, respectively). The cardioprotective efficacy of cariporide has been examined in clinical investigations of patients at risk for myocardial infarction. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)-benzamide, HOE 642 |
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| Gene, Accession, CAS # | CAS: 159138-80-4 |
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| Catalog # | LS-H7001 |
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| Order / More Info | Cariporide from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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