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| Product Name | Phosphoglycerate Dehydrogenase (PHGDH) Activity Assay Kit (Colorimetric) |
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| Description | Phosphoglycerate Dehydrogenase (PHGDH: EC 1.1.1.95) is the first enzyme that participates in the L-serine synthesis pathway. PHGDH catalyzes the reversible reaction that converts 3-phosphoglycerate into 3-phosphohydroxyglycerate and the NADH-dependent reduction of α-ketoglutarate into D-2-hydroxyglutarate (D-2HG). In humans, PHGDH deficiency causes severe health problems including congenital microcephaly, psychomotor retardation, and intractable seizure. Recent studies have shown increased PHGDH activity in a wide variety of cancers, particularly in breast and melanoma tumors. Therefore, the measurement of PHGDH activity has become of great importance in searching potential therapeutic agents against cancer. BioVision's Phosphoglycera |
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| Size | 100 assays |
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| Concentration | n/a |
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| Applications | Measurement of PHGDH activity in purified/crude enzyme preparations and biological samples such as cell/tissue lysates |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | K569-100 |
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| Order / More Info | Phosphoglycerate Dehydrogenase (PHGDH) Activity Assay Kit (Colorimetric) from BIOVISION, INC. |
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| Product Specific References | n/a |
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