| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | IRS1 |
|---|
| Clone | 529Q21 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, mouse, rat |
|---|
| Isotype | IgG1, kappa |
|---|
| Format | purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blot: Assay Dependent |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | IRS1 Monoclonal Antibody (529Q21). Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic option. To date there have been four subtypes identified: IRS-1,2,3, and 4, with |
|---|
| Immunogen | n/a |
|---|
| Other Names | IRS-1, IRS1, Insulin receptor substrate-1 |
|---|
| Gene, Accession # | Entrez: 16367, 25467, 3667; Uniprot: P35568, P35569, P35570 |
|---|
| Catalog # | AHO1322 |
|---|
| Price | |
|---|
| Order / More Info | IRS1 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|