| 产品详情 |
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| Antigenic Specificity | IRS1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 20 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:200-1:1,000, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IRS1 Polyclonal Antibody. IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insuli |
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| Immunogen | n/a |
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| Other Names | Phospho-Insulin Receptor Substrate-1 |
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| Gene, Accession # | Entrez: 16367, 3667; Uniprot: P35568, P35569 |
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| Catalog # | A301-158A-T |
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| Price | |
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| Order / More Info | IRS1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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