| 产品详情 |
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| Antigenic Specificity | MIP-3α/CCL20 |
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| Clone | 319F6.07 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b |
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| Format | purified |
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| Size | 100µg/50µg |
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| Concentration | n/a |
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| Applications | ELISA capture, Blocking migration of DCs, IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Macrophage inflammatory protein (MIP)-3alpha/ CCL20 is a CC-type chemokine mapped to chromosome 2 in humans. Langerhans cells (LCs) represent a unique population of DCs colonizing epithelium. MIP-3alpha plays a central role in LC precursor recruitment into the epithelium during inflammation. (a) Among DC populations, MIP-3alpha is the most potent chemokine inducing the selective migration of in vitro-generated CD34(+) hematopoietic progenitor cell-derived LC precursors and skin LCs in accordance with the restricted MIP-3alpha receptor (CC chemokine receptor 6) expression by these cells. (b) MIP-3alpha is mainly produced by epithelial cells, and the migration of LC precursors induced by the supernatant of activated skin keratinocytes is blocked with an antibody against MIP-3alpha. (c) In vivo, MIP-3alpha is selectively produced at sites of inflammation as illustrated in tonsils and lesional psoriatic skin where MIP-3alpha upregulation appear associated with an increase in LC turnover. (d) The secretion of MIP-3alpha is strongly upregulated by cells of epithelial origin after inflammatory stimuli (interleukin 1beta plus tumor necrosis factor alpha) or T cell signals.(Dieu-Nosjean et al, J;Exp.med, 2000 192: 705-18) |
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| Immunogen | n/a |
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| Other Names | Macrophage inflammatory protein (MIP)-3alpha/ CCL20 |
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| Gene, Accession # | n/a |
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| Catalog # | DDX0430 |
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| Price | |
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| Order / More Info | MIP-3α/CCL20 Antibody from DENDRITICS SAS |
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| Product Specific References | n/a |
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