| 产品详情 |
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| Product Name | SNS-314 (mesylate) |
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| Description | Purity >98%. SNS-314 is a pan-Aurora kinase inhibitor (IC50 s = 9, 31, and 3.4 nM for Aurora A, B, and C, respectively). In a panel of 219 kinases, SNS-314 also inhibits TRKB, TRKA, FLT4, FMS, DDR2, AXL, and C-RAF (IC50 s = 5-100 nM). SNS-314 inhibits Aurora B phosphorylation of histone H3 in HCT116 human colorectal carcinoma cells in vitro (EC50 = <16 nM) and in a mouse xenograft model at a dose of 50 mg/kg. It also inhibits tumor growth in A2780 ovarian, A375 melanoma, H1299 lung, MDA-MB-231 breast, and PC3 prostate cancer mouse xenograft models when administered biweekly for six weeks at a dose of 170 mg/kg. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-urea, monomethanesulfonate |
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| Gene, Accession, CAS # | CAS: 1146618-41-8 |
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| Catalog # | LS-H9961 |
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| Price | |
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| Order / More Info | SNS-314 (mesylate) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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