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| Antigenic Specificity | Glutamic Acid Decarboxylase (GAD65) |
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| Clone | N-GAD65 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), IHC, Immunofluorescence Microscopy (IF), IP |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Glutamic Acid Decarboxylase (GAD65/GAD2). GAD gene encodes one of the several forms of glutamic acid decarboxylase, which is identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid (GABA) from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. GAD65 targets presynaptic clusters in axons and exhibits relative dendritic exclusion. GAD65 synthesizes GABA for neurotransmission and is only necessary at nerve terminals and synapses. In order to aid in neurotransmission, GAD65 forms a complex with Heat Shock Cognate 70 (HSC70), cysteine string protein (CSP) and Vesicular GABA transporter (VGAT), which, as a complex, helps package GABA into vesicles for release during neurotransmission. |
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| Immunogen | Peptide immunogen corresponding to amino acids 4-22 of human GAD65. |
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| Other Names | Glutamate Decarboxylase 2, GAD65, Glutamate Decarboxylase 65 kD Isoform, GABA |
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| Gene, Accession # | Gene ID: 2572 |
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| Catalog # | 844502 |
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| Price | |
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| Order / More Info | Glutamic Acid Decarboxylase (GAD65) Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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