| 产品详情 |
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| Product Name | 1-NM-PP1 |
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| Description | Purity >95%. 1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 µM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 µM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 µM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 µM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, PP1 Analog II |
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| Gene, Accession, CAS # | CAS: 221244-14-0 |
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| Catalog # | LS-H5900 |
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| Price | |
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| Order / More Info | 1-NM-PP1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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