| 产品详情 |
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| Product Name | NMS-873 |
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| Description | Purity >98%. The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50 s >10 µM). It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[3-(cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]-pyridine, VCP Inhibitor III |
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| Gene, Accession, CAS # | CAS: 1418013-75-8 |
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| Catalog # | LS-H9023 |
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| Price | |
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| Order / More Info | NMS-873 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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