| 产品详情 |
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| Product Name | Tideglusib |
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| Description | Purity >98%. Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARGamma antagonist GW9662 . Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3Beta (GSK3Beta) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation. Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer's therapy. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-(1-naphthalenyl)-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione, NP031112 |
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| Gene, Accession, CAS # | CAS: 865854-05-3 |
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| Catalog # | LS-H10220 |
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| Order / More Info | Tideglusib from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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